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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Mutat Res Genet Toxicol Environ Mutagen. 2023 May 20;889:503649. doi: 10.1016/j.mrgentox.2023.503649

Figure 2.

Figure 2.

A. Mutation frequency in TK6 cells exposed to ENU measured by Duplex Sequencing (TwinStrand Biosciences). B. Linear correlation of mutation frequency measured at HC and Inotiv-RTP. Cells were sampled after 48, 72, and 96 h following the initial exposure (n=2/ concentration and time point). Library construction and sequencing were completed by TwinStrand. Numbers above the bars represent non-normalized mutation counts. Frequency was determined by dividing the counts by the total number of BP sequenced. There was a significant concentration main effect (Holm-Sidak adjusted p-value < 0.0001) and concentration by lab interaction (Holm-Sidak adjusted p-value < 0.0001). There was no statistically significant difference in mutation frequency across the three time points.