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KATP channel isoforms and selected Kir6.2/SUR1 channel openers. (A) Diversity of KATP isoforms and their tissue-specific expression. (B) Structures of representative Kir6.2/SUR1 channel openers 1–4.6,11,12,13,16 aReported EC50 value; EC50 was 0.75 ± 0.08 μM (Mean ± SEM, n = 6 experiments) in thallium flux assays with T-REx-HEK293 cells
