Table 5.
NO Nanomedicines for Wound Healinga
| Nanomedicine | NO donor | Release condition | Working mechanism of NO | Refs |
|---|---|---|---|---|
| SNP@UCM | Sodium nitroprusside | NIR irradiation | Promoting HIF-1α expression, VEGF secretion, and endothelial cell proliferation and migration. | 249 |
| PU/Gelatin/KSNO | R-SNO | Physiological conditions | Promoting cell proliferation and adhesion to accelerate wound healing | 130 |
| TP-Por CON | BNN6 | 635 nm irradiation (Photothermal) | NO/PTT/PDT synergistically kill Gram-positive/negative bacteria via ONOO− | 250 |
| pH@MSN-CaP-NO | diazeniumdiolate | pH 5.0 | NO promotes cornea wound healing | 147 |
| BP1 Vesicles | oNBN, pNBN, BN | UV 365 nm irradiation | NO increases cell migration and viability | 149 |
| HA-NO | Diazeniumdiolate | Physiological conditions | NO as an antibacterial agent for promoting wound healing | 98 |
| GelMA/HA-DA/GO-βCD-BNN6 | BNN6 | 808 nm laser irradiation (Photothermal) | Promoting new blood vessels and collagen deposition to accelerate wound healing | 134 |
| MoS2-BNN6 | BNN6 | 808 nm laser irradiation (Photothermal) | NO kills the bacteria by damaging DNA, promotes the formation of collagen fibers, and reduces inflammation during wound tissue reconstruction | 251 |
| Ch/PAs-Cu | R-SNO | Cu2+ | NO combats bacteria and accelerates wound healing | 131 |
| PB-NO | R-NO | 808 nm laser irradiation (Photothermal) | Promoting new blood vessels and collagen deposition to accelerate wound healing | 132 |
| Arg-ADP | L-Arg | H2O2 | NO/PDT synergistically overcomes bacterial infections and promotes wound healing | 135 |
| NO@HKUST1/PCL/Gel | NONOate | Physiological conditions | Promoting endothelial cell growth, significantly improving angiogenesis and collagen deposition, and reducing inflammatory effects in the wound | 138 |
| FBN/PEG | NONOate | Physiological conditions | NO enhances reepithelialisation, collagen deposition, and blood vessel formation | 252 |
| AhCeO2 NPs | L-Arg | H2O2 | NO promotes cellular proliferation | 253 |
| MA-HA-(MEDN)-NONOates | NONOate | Physiological conditions | Effectively promoting proliferation and migration of fibroblasts | 254 |
| CS-PAMAM/NONOate | NONOate | Physiological conditions | NO antibacterial to accelerate wound healing | 255 |
SNP@UCM, SNP@MOF-UCNP@ssPDA-Cy7/IR786s; PU/Gel/KSNO, polyurethane/gelatin/S-nitrosated keratin; TP-Por CON, porphyrin-based COF nanosheets; BP Vesicles, PEO45-b-PoNBNn Vesicles; HA-NO, hyaluronic acid-NO; GelMA/HA-DA/GO-βCD-BNN6, methacrylate-gelatin/hyaluronic acid-dopamine hydrogel/ graphene oxide-β-cyclodextrin-BNN6; Ch/PAs-Cu, chitin sponges-proanthocyanidins-Cu2+; PB-NO, Prussian blue-NO; Arg-ADP, L-Arginine-rich amphiphilic dendritic peptide; NO@HKUST1/PCL/Gel, NO@ copper-based metal–organic framework/hydrophobic polycaprolactone/gelatin; FBN/PEG, Pluronic F127-branched polyethylenimine-1-substituted diazen-1-ium-1,2-diolates/PEG; AhCeO2 NPS, hollow CeO2-L-arginine nanoparticles; MA-HA-(MEDN)-NONOates, methacrylate-hyaluronic acid-N-diazeniumdiolate; CS-PAMAM/NONOate, Polyamidoamine dendrimer-grafted chitosan/NONOate.