Table 1.
Variables in the somnolence (n = 30 volunteers) and no-somnolence (n = 29 volunteers) groups of the first case-control study.
| Variables | Total volunteers (n = 59) | Somnolence group (n = 30) | No-somnolence group (n = 29) | statistics | p-value |
|---|---|---|---|---|---|
| Gender | χ2 = 0.060 | 0.807 | |||
| Female | 13 (22.0%) | 7 (23.3%) | 6 (20.7%) | ||
| Male | 46 (78.0%) | 23 (76.7%) | 23 (79.3%) | ||
| Age (y) | 28.0 (22.0, 33.0) | 25.0 (21.0, 31.2) | 29.0 (23.0, 36.0) | Z = −1.732 | 0.083 |
| Height (m) | 1.70 (1.60, 1.75) | 1.70 (1.58, 1.76) | 1.70 (1.62, 1.75) | Z = −0.144 | 0.885 |
| Weight (kg) | 63.79 ± 8.36 | 63.51 ± 9.05 | 64.08 ± 7.72 | t = 0.260 | 0.796 |
| Fed condition | χ2 = 6.166 | 0.013* | |||
| Fasting | 25 (42.4%) | 8 (26.7%) | 17 (58.6%) | ||
| Fed | 34 (57.6%) | 22 (73.3%) | 12 (41.4%) | ||
| Cmax (ng/mL) | 55.05 (22.85, 92.80) | 64.90 (45.90, 96.79) | 26.75 (15.65, 70.50) | Z = −2.881 | 0.004* |
| Tmax (h) | 2.00 (1.50, 3.00) | 1.75 (1.25, 2.31) | 2.50 (2.00, 3.25) | Z = −3.355 | 0.001* |
| AUC0-∞ (ng × h/mL) | 201.50 (124.50, 305.50) | 236.25 (164.13, 298.25) | 127.00 (82.70, 312.25) | Z = −2.077 | 0.038* |
*p < 0.05.