Table 3.
Independent variables in the somnolence (n = 30 volunteers) and no-somnolence (n = 29 volunteers) groups and the associations between each variable and risk of somnolence in the first case-control study.
| Variables | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| Gender | ||||
| Male | 0.857 (0.250–2.945) | 0.807 | ||
| Female | 1 | |||
| Age (y) | 0.954 (0.900–1.012) | 0.117 | ||
| Height (m) | 0.302 (0.001–93.678) | 0.682 | ||
| Weight (kg) | 0.992 (0.932–1.055) | 0.792 | ||
| Fed condition | ||||
| Fasting | 1 | |||
| Fed | 3.896 (1.302–11.655) | 0.015* | NS | 0.233 |
| Plasma concentration at each time point | ||||
| 0 h | 3.737 (0.002–7389.434) | 0.734 | ||
| 0.25 h | 2.334 (1.122–4.853) | 0.023* | NS | 0.245 |
| 0.5 h | 1.234 (1.093–1.394) | 0.001* | NS | 0.077 |
| 0.75 h | 1.140 (1.059–1.227) | 0.001* | NS | 0.105 |
| 1 h | 1.124 (1.052–1.201) | 0.001* | 1.124 (1.052–1.201) | 0.001* |
| 1.5 h | 1.088 (1.040–1.137) | <0.001* | NS | 0.395 |
| 2 h | 1.044 (1.014–1.075) | 0.003* | NS | 0.343 |
| 2.5 h | 1.014 (0.995–1.033) | 0.152 | ||
| 3 h | 1.005 (0.987–1.025) | 0.574 | ||
| 3.5 h | 1.001 (0.979–1.023) | 0.941 | ||
| 4 h | 0.994 (0.967–1.020) | 0.632 | ||
| 5 h | 0.981 (0.950–1.013) | 0.241 | ||
| 6 h | 0.969 (0.911–1.030) | 0.307 | ||
| 8 h | 0.985 (0.815–1.189) | 0.873 | ||
| 12 h | 1.035 (0.656–1.633) | 0.881 | ||
| 24 h | 1.256 (0.429–3.678) | 0.677 | ||
| 36 h | 1.908 (0.391–9.307) | 0.424 | ||
| 48 h | 5.025 (0.735–34.353) | 0.10# | NS | 0.459 |
*p < 0.05; #p ≤ 0.1; NS indicates no statistical significance.