Table 4.
Independent variables in the somnolence (n = 48 times) and no-somnolence (n = 48 times) groups and the associations between each variable and risk of somnolence in the second case-control study.
| Variables | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| Preparation | ||||
| Reference | 1 | |||
| Test | 1 (0.449–2.226) | 1 | ||
| Plasma concentration at each time point | ||||
| 0 h | 2376.793 (0.143–39601923.360) | 0.117 | ||
| 0.25 h | 1.50 (1.146–1.962) | 0.003* | NS | 0.162 |
| 0.5 h | 1.072 (1.026–1.121) | 0.002* | NS | 0.580 |
| 0.75 h | 1.042 (1.016–1.070) | 0.002* | 1.042 (1.016–1.070) | 0.002* |
| 1 h | 1.034 (1.012–1.056) | 0.002* | NS | 0.635 |
| 1.5 h | 1.015 (0.999–1.032) | 0.058# | NS | 0.752 |
| 2 h | 1.003 (0.985–1.020) | 0.772 | ||
| 2.5 h | 0.992 (0.971–1.012) | 0.430 | ||
| 3 h | 0.989 (0.967–1.012) | 0.341 | ||
| 3.5 h | 0.993 (0.967–1.019) | 0.581 | ||
| 4 h | 0.996 (0.965–1.028) | 0.817 | ||
| 5 h | 0.980 (0.946–1.015) | 0.260 | ||
| 6 h | 0.965 (0.905–1.029) | 0.275 | ||
| 8 h | 0.926 (0.768–1.117) | 0.421 | ||
| 12 h | 0.943 (0.619–1.434) | 0.782 | ||
| 24 h | 0.902 (0.274–2.967) | 0.865 | ||
| 36 h | 1.937 (0.422–8.891) | 0.395 | ||
| 48 h | 2.344 (0.425–12.925) | 0.328 | ||
*p < 0.05; #p ≤ 0.1; NS indicates no statistical significance.