ADMET screening of the synthesized compounds.

Comp.	BBB level	Solubility level	Absorption level	Hepatotoxic prediction	CYP2D6 prediction	PPB prediction
15a	Very low	Low	Moderate	Non-toxic	Non-inhibitor	<90%
15b		Good
16		Low
17		Good		Toxic
Sorafenib		Very low	Good			>90%