Table 4.

Association between Prospective Exacerbation and T Cells and Their Activation Markers

Marker	IRR (95% CI)	Adjusted P
Percent CD4+ cells in CD45+ (n = 125)*	0.16 (0.06–0.46)	0.001
Percent CD8+ cells in CD45+ (n = 126)*	0.31 (0.13–0.70)	0.005
CD4+ CCR5 MFI (n = 127)†	3.02 (0.85–10.7)	0.087
CD4+ CTLA4 MFI (n = 127)†	3.45 (1.48–8.01)	0.004
CD8+ CCR5 MFI (n = 123)†	4.23 (1.06–16.9)	0.041
CD8+ CTLA4 MFI (n = 124)†	2.91 (1.04–8.11)	0.042

Definition of abbreviations: CI = confidence interval; IRR = incident risk ratio; MFI = mean fluorescence intensity.

IRRs are shown for each 1-SD increase of each predictor.

^*Zero-inflated Poisson model adjusted for sex, age, current smoking status, and FEV₁% predicted.

^† Zero-inflated Poisson model adjusted for sex, age, and control fluorescent bead batch.