Table 2.
Adverse Neonatal Outcomes
| Hemodynamic Screening (n = 191) | Historical Control Subjects (n = 423) | P Value | |
|---|---|---|---|
| Primary outcome | |||
| Composite of death/severe IVH | 29 (15) | 122 (29) | <0.001 |
| Secondary outcomes | |||
| Survival free of severe morbidity (NEC, grade III BPD, severe IVH) | 155 (81) | 264 (66) | <0.001 |
| Neurological | |||
| Severe IVH | 13 (7) | 81/402 (20) | <0.001 |
| All grades of IVH | 31/187 (17) | 123/393 (31) | <0.001 |
| Respiratory | |||
| Bronchopulmonary dysplasia (at 36 wk) | |||
| Ventilator dependent (grade III) | 11 (7) | 48 (13) | 0.02 |
| Noninvasive positive pressure (grade II) | 124 (74) | 219 (61) | 0.008 |
| Death/grade III BPD at 36 wk | 30 (17) | 124 (29) | 0.002 |
| Pulmonary hemorrhage | 2 (1) | 15 (4) | 0.11 |
| Pneumothorax | 5 (3) | 36/415 (9) | 0.005 |
| Cardiovascular | |||
| PDA medical treatment | 139 (73) | 228/373 (61) | 0.007 |
| PDA intervention (surgery/percutaneous) | 48 (25) | 135/315 (65) | <0.001 |
| Gastrointestinal | |||
| Intestinal perforation | 11 (6) | 25 (6) | 0.94 |
| Necrotizing enterocolitis | 2 (1) | 26 (6) | <0.001 |
| Ophthalmologic | |||
| Laser/bevacizumab treatment for ROP | 15/189 (8) | 20 (6) | 0.36 |
| Mortality characteristics | |||
| Death | 21 (12) | 76 (18) | 0.03 |
| Age at death | 13 [6, 38] | 7 [2, 22] | 0.07 |
| Death in the first postnatal week | 6 (3) | 37 (9) | 0.027 |
Definition of abbreviations: BPD = bronchopulmonary dysplasia; IVH = intraventricular hemorrhage; NEC = necrotizing enterocolitis; PDA = patent ductus arteriosus; ROP = retinopathy of prematurity.
Data are presented as median [interquartile range] or frequency (percent).