Table 1.
Invasive Hemodynamic Response to Acute Hypoxia Derived from Pulmonary Arterial and Conductance Catheterization
| FiO2 = 0.21 | FiO2 = 0.17 | FiO2 = 0.15 | FiO2 = 0.12 | P Value | |
|---|---|---|---|---|---|
| Swan-Ganz catheter (N = 5) | |||||
| HR, bpm | 53 (50, 62) | 54 (52, 62) | 55 (53, 72) | 63 (53, 73) | 0.06 |
| RAP, mm Hg | 3 (1, 3) | 3 (1, 3) | 3 (1, 3) | 1 (0, 2]*†‡ | <0.01 |
| PAS, mm Hg | 18 (14, 20) | 17 (15, 22) | 20 (16, 22)* | 25 (25, 31)*†‡ | <0.01 |
| PAD, mm Hg | 8 (4, 10) | 9 (8, 11) | 9 (8, 11) | 9 (7, 13) | 0.25 |
| mPAP, mm Hg | 12 (7, 13) | 12 (11, 13) | 13 (13, 13) | 14 (13, 19)* | 0.01 |
| PAWP, mm Hg | 6 (6, 6) | 6 (6, 7) | 5 (4, 10) | 6 (3, 10) | 0.92 |
| PA Sat, % | 71 (69, 72) | 64 (64, 67) | 64 (58, 64)* | 53 (49, 61)*†‡ | <0.01 |
| Arterial Sat, % | 96 (94, 97) | 93 (89, 96) | 86 (83, 90)*† | 76 (71, 81)*†‡ | <0.01 |
| SV, ml/beat | 125 (101, 151) | 107 (80, 184) | 114 (97, 174) | 147 (124, 166) | 0.69 |
| Qc, L/min | 7.4 (6.1, 8.7) | 6.2 (5.8, 8.8) | 8.2 (6.8, 9.2) | 9.7 (7.2, 11.3) | 0.40 |
| PVR, WU | 0.9 (0.5, 1.0) | 1.0 (0.8, 1.1) | 1.1 (0.5, 1.1) | 1.0 (1.0, 1.1) | 0.10 |
| Conductance catheter (N = 5) | |||||
| RV contractility | |||||
| dPdtmax, mm Hg/s | 268 (240, 271) | 283 (257, 312) | 315 (296, 340) | 448 (342, 476)*†‡ | <0.01 |
| ESP, mm Hg | 17 (17, 18) | 19 (18, 21) | 23 (19, 23) | 27 (23, 28)*† | <0.01 |
| PRSW, mm Hg | 7 (6, 13) | 14 (12, 14) | 14 (14, 19) | 20 (11, 26)* | 0.02 |
| RV lusitropy | |||||
| dPdtmin, mm Hg/s | −208 (−219, −195) | −243 (−260, −225) | −275 (−297, −232) | −331 (−396, −295)*†‡ | <0.01 |
| RV energetics | |||||
| SW, mm Hg ⋅ ml | 1,750 (1,489, 2,697) | 2,777 (2,697, 2,900) | 3,503 (3,229, 3,536) | 3,578 (2,558, 5,440)* | 0.03 |
| Ventricular-arterial coupling | |||||
| EES, mm Hg/ml | 0.21 (0.19, 0.25) | 0.19 (0.18, 0.25) | 0.23 (0.18, 0.25) | 0.24 (0.20, 0.25) | 0.54 |
| EA, mm Hg/ml | 0.16 (0.15, 0.17) | 0.13 (0.11, 0.15) | 0.14 (0.12, 0.15) | 0.18 (0.14, 0.18)†‡ | 0.02 |
| EES/EA, units | 1.51 (1.35, 1.73) | 1.50 (1.42, 1.62) | 1.43 (1.32, 1.84) | 1.35 (1.33, 1.41) | 0.47 |
Definition of abbreviations: Arterial Sat = arterial oxygen saturation; bpm=beats per minute; dPdtmax = maximum rate of pressure change; dPdtmin = minimum rate of pressure change; EA = effective arterial elastance; EES = end-systolic elastance; EES/EA = ventricular-arterial coupling; ESP = end-systolic pressure; HR = heart rate; mPAP = mean pulmonary arterial pressure; PA Sat = pulmonary arterial oxygen saturation; PAD = pulmonary arterial diastolic; PAS = pulmonary arterial systolic; PAWP = pulmonary artery wedge pressure; PRSW = preload recruitable stroke work; PVR = pulmonary vascular resistance; Qc = cardiac output; RAP = right atrial pressure; RV = right ventricular; SV = stroke volume; SW = stroke work; WU = Wood units.
Data are presented as median (interquartile range).
P < 0.05 for comparison with an FiO2 of 0.21.
P < 0.05 for comparison with an FiO2 of 0.17.
P < 0.05 for comparison with an FiO2 of 0.15.