Table 1. Summary of DHODH.

Class	Form	Electron Acceptor	Localisation	Catalytic base	Species distribution
1A	Homodimer	FMN	Cytosol	Cysteine	Gram-positive bacteria, such as Streptococcus mutans [21]; Parasites such as Leishmania major [22] and Trypanosoma spp. [23, 24]; Saccharomyces cerevisiae [25]; Mucorales, predicted [4]
1B	Heterotetramer	NAD+	Cytosol	Cysteine	Gram-positive bacteria such as Bacillus subtilis [26], Clostridium oroticum [27] and Bifidobacterium bifidum [28]
1S	Heterodimer	Coenzyme Q, O2	Cytosol	Serine	Sulfolobus solfataricus [29]
2	Monomer	Quinones	Cell membrane [30] or inner mitochondrial membrane [31]	Serine	Gram-negative bacteria [32]; Plasmodium spp. [33]; Plants [34]; Insects [31]; Mammals [35]; Most fungi, including Aspergillus spp. [36], Candida spp. [37]; Dematiaceous moulds, predicted [4]