Table 5. Olorofim sensitivity of heterologous yeast strains expressing DHUO.

The geometric mean (GM) MIC and MIC range are presented for a wild-type (WT) strain and heterologous strains expressing either the class 2 DHODH from A. fumigatus (AF) or the DHUO from A. alternata (AA), C. bantiana (CB), E. dermatitidis (ED), F. pedrosoi (FP), M. mycetomatis (MM), P. americana (PA) and P. minimum (PM).

		ura1Δ +
	WT	AF	AA	CB	ED	FP	MM	PA	PM
GM (mg/L)	>8	0.125	>8	>8	>8	>8	>8	>8	>8
Range (mg/L)	>8	0.125	>8	>8	>8	>8	>8	>8	>8