Fig 1. M1/ M2 polarization and modified Rodnan total skin thickness score in dcSSc patients.

(A) Representative dot plots show the gating strategy for identification of CD80⁺CD163^-, CD80⁺CD206^-, CD80^-CD163^+, and CD80^-CD206⁺ macrophage subsets. (B) Correlations between the proportions of CD80⁺CD163^- or CD80⁺CD206^- cells in monocyte-derived macrophages (MDM) 1 and CD80^-CD163⁺ or CD80^-CD206⁺ cells in MDM2 to CD68⁺ cells and mRSS in patients with diffuse cutaneous systemic sclerosis (dcSSc). Correlations were determined using Spearman’s rank correlation test. Solid lines represent regression lines.