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The RAF isoforms indicating the conserved regions (CR): CR1 (orange), CR2 (grey), and CR3 (blue). Labeled within the three regions are RAS-binding domain (RBD)/cysteine-rich domain (CRD), serine/threonine rich domain (S/T Rich), and kinase domain contained in CR1/CR2/CR3, respectively. On BRAF, there is a BRAF-specific region (red) located at the N-terminus. The amino acid numbers of the beginning and end of the RAF isoform and CR are shown.
