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. 2023 Jun 23;325(2):H323–H337. doi: 10.1152/ajpheart.00154.2023

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Copyright © 2023 The Authors.

Licensed under Creative Commons Attribution CC-BY 4.0. Published by the American Physiological Society.

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Figure 5. — Effects of a single and repeated exposures to ODN2395 on circulating proinflammatory cytokines and monocyte chemoattractants in nonpregnant (NP) and pregnant rats. A–B: proinflammatory cytokines (A) and monocyte chemoattractants (B) in plasma of nonpregnant, gestational day (GD) 14 dams (cohort 1), and GD20 dams (cohort 2) intraperitoneally administered ODN2395 or saline vehicle. Nonpregnant and GD14 dams received a single intraperitoneal injection while GD20 dams received three sequential intraperitoneal injections of ODN2395 or saline vehicle. Values are presented as means ± SD (n = 7–9/group) and were analyzed by unpaired t test. Black circles, saline; red boxes, ODN2395; TNF-α, tumor necrosis factor-α, IL-1 α, interleukin-1α; IL-12p70, bioactive dimer of interleukin-12 p35 and p40 subunits; IL-17A, interleukin-17A; MCP-1, monocyte chemoattractant protein-1; MIP-3α, macrophage inflammatory protein-3α; RANTES, regulated on activation, normal T cell expressed and secreted. ODN, oligodeoxynucleotides.