Figure 7.

Effect of a single exposure to ODN2395 on clock gene expression in rat placentas on gestational day 14. Placental gene expression of circadian rhythm regulators circadian locomotor output cycles protein kaput (Clock), brain and muscle ARNT [Aryl hydrocarbon receptor nuclear translocator-like protein]-like protein-1 (Bmal1), cryptochrome circadian regulator 1 (Cry1), and period circadian protein homologs 1, 2, and 3 (Per1, Per2, and Per3, respectively) 4 h after administration of ODN2395 or saline vehicle. Values are presented as means ± SD (n = 6–7/group) and were analyzed by unpaired t test. ODN, oligodeoxynucleotides.