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. 2023 Jun 15;325(2):F199–F213. doi: 10.1152/ajprenal.00086.2023

Figure 2.

Figure 2.

Elevated urinary acute kidney injury biomarkers following prolonged mild hypohydration. Healthy males (n = 11) and females (n = 11) underwent 24-h fluid deprivation (hypohydrated group) or 24-h normal fluid consumption (euhydrated group). A: product of insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase (TIMP)-2 ([IGFBP7·TIMP-2]). B: IGFBP7. C: TIMP-2. D: kidney injury molecule-1 (KIM-1). E: neutrophil gelatinase-associated lipocalin (NGAL). Data were analyzed with two-way ANOVA with factors of sex and hydration and post hoc Holm–Šídák tests for multiple comparisons. P values from main effects (sex and hydration) and interaction (sex × hydration) are shown at the top, and exact P values from multiple-comparison adjustments are shown above a given comparison. Data are presented as means with 95% confidence intervals and individual values.