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. 2023 Jun 15;325(2):F199–F213. doi: 10.1152/ajprenal.00086.2023

Figure 3.

Figure 3.

Urine osmolality-corrected (A, C, E, G, and I) and urine creatinine-corrected (B, D, F, H, and J) corrected acute kidney injury biomarker responses to prolonged mild hypohydration. Healthy males (n = 11) and females (n = 11) underwent 24-h fluid deprivation (hypohydrated group) or 24-h normal fluid consumption (euhydrated group). A and B: product of insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinase (TIMP)-2 ([IGFBP7·TIMP-2]). C and D: IGFBP7. E and F: TIMP-2. G and H: kidney injury molecule-1 (KIM-1). I and J: neutrophil gelatinase-associated lipocalin (NGAL). Data were analyzed with two-way ANOVA with factors of sex and hydration and post hoc Holm–Šídák tests for multiple comparisons. P values from main effects (sex and hydration) and interaction (sex × hydration) are shown at the top, and exact P values from multiple-comparison adjustments are shown above a given comparison. Data are presented as means with 95% confidence intervals and individual values.