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. 2023 Jun 22;14(22):2093–2104. doi: 10.1111/1759-7714.14989

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© 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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AHNAK2 downregulation suppresses cell cycle in A549 cells. (a, b) Pathway enrichment: differential genes were enriched to focal adhesion, cell cycle, DNA replication, NF‐kappa B signaling pathway and so forth. (c) Gene ontology (GO) enrichment: differential genes were enriched to cell cycle G1/S phase transition, chromosome segregation and protein‐DNA complex subunit organization. (d) Correlation of the mRNA levels of AHNAK2 and CCND1 (left) and RUVBL1 and PCNA (right) in TCGA lung adenocarcinoma (LUAD) tumor samples. (e) PCNA and CCND1 were downregulated in the A549 cells transfected with AHNAK shRNA and RUVBL1 siRNA in sequence, while CDKN1A(P21) expression increased.