Skip to main content
. 2023 Jul 19;620(7972):128–136. doi: 10.1038/s41586-023-06331-x

Fig. 1. T cell reactivity in pre-pandemic samples from individuals carrying HLA-B*15:01.

Fig. 1

a–c, Ex vivo combinatorial tetramer analysis for the four indicated peptides was performed in nine pre-pandemic donor samples. a,b, The number of donors with detectable tetramer+CD8+ T cells (a) and their frequencies (b) are shown. c, The proportion of naive (CD45RA+CCR7+) and memory (combination of CD45RA−CCR7−, CD45RA−CCR7+, CD45RA+CCR7−) cells among tetramer+CD8+ T cells (based on n = 9 samples). d, Phenotypic analysis after TAME of ex vivo tetramer+ NQK-Q8-specific (tet-Q8) and NQK-A8-specific (tet-A8) T cells in 7 and 6 donors, respectively. Cell types were defined as follows: Tnaive (CD45RA+CCR7+CD95−); TSCM (stem cell memory, CD45RA+CCR7+CD95+); TCM (central memory, CD45RA−CCR7+); TEM (effector memory, CD45RA−CCR7−); TEMRA (terminally differentiated, CD45RA+CCR7−). Data are mean ± s.e.m.