Table 1.
HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection
| Asymptomatic | Symptomatic | |||||
|---|---|---|---|---|---|---|
| cf | cf | OR | 95% CI | P | Padj | |
| Discovery cohort | ||||||
| HLA-B*15:01 | 0.199 | 0.094 | 2.40 | 1.54–3.64 | 5.67 × 10−5 | 0.002 |
| HLA-B*15:01/15:01 | 0.022 | 0.005 | 8.58 | 1.74–34.43 | 0.001 | |
| UK cohort | ||||||
| HLA-B*15:01 | 0.171 | 0.070 | 3.56 | 1.15–10.97 | 0.02 | |
| CHIRP/LIINC cohort | ||||||
| HLA-B*15:01 | 0.250 | 0.086 | 3.44 | 0.50–23.64 | 0.13 |
Results are shown for two-sided tests based on a generalized linear model, including adjustment for sex and age. cf, carrier frequency. The ORs are relative to non-HLA-B*15:01 carriers.