TABLE 2.
Susceptibility of primed mice to challenge with the H3N8 virusa
| Mouse strain | T-cell depletionb | Mean survival time (days) ± SD
|
|
|---|---|---|---|
| Naive mice | Immune mice | ||
| B6 | Nil | 5.6 ± 0.6 | >21 |
| CD4 | 4.3 ± 0.5 | >21 | |
| CD8 | 4.8 ± 0.5 | >21 | |
| CD4 + CD8 | 5.3 ± 1.3 | >21 | |
| μMT | Nil | 7.5 ± 2.9 | 6.1 ± 1.0, 4.7 ± 2.1c |
a
B6 and μMT mice were infected i.n. with 106.8 EID50 of the H3N2 virus and rested for 2 to 4 months. Groups of four mice were challenged i.n. with 104.0 EID50 of the H3N8 virus. The data are cumulated from several experiments and are for a total of 8 to 12 mice for each treatment.
b
The mice were treated with MAb GK1.5 to CD4, MAb 2.43 to CD8, or rat Ig as a control (Nil), commencing 5 days prior to challenge and continuing every 2 or 3 days thereafter (20).
c
This group of μMT mice was primed i.p. with 105.2 EID50 of the H3N8 virus and rested for 7 weeks prior to i.n. challenge with 104.0 EID50 of the H3N8 virus.