表5 年龄≥40岁采用三种COH方案的再生育继发不孕妇女IVF-ET治疗效果比较
Table 5 Comparison of the stimulation effects and clinical outcomes of GnRH agonist long protocol, GnRH agonist short protocol and GnRH antagonist protocol in secondary infertile women≥40 years
|
( x ± s) | ||||
|
指标 |
GnRH激动剂长方案( n=41) |
GnRH激动剂短方案( n=114) |
GnRH拮抗剂方案( n=45) |
P值 |
|
女方年龄(岁) |
41.41±1.50 |
41.75±1.81 |
41.80±1.49 |
0.406 |
|
移植胚胎数 |
2.15±0.99 |
1.88±1.07 |
1.82±1.21 |
0.373 |
|
血基础卵泡刺激素(U/L) |
8.72±3.37 |
7.52±3.09 |
7.12±2.82 *# |
0.013 |
|
促性腺激素总量(U) |
2 694.51±1 099.90 |
2 297.15±780.28 * |
2 412.78±738.10 |
0.038 |
|
注射促性腺激素天数(d) |
10.24±3.07 |
8.75±2.57 * |
9.49±2.76 |
0.004 |
|
注射HCG日血雌二醇(pmol/L) |
10 601±6 935.81 |
9 339.85±5 970.86 |
5 893.81±4 107.50 *# |
< 0.001 |
|
注射HCG日血黄体生成素(U/L) |
2.08±1.40 |
5.31±3.04 * |
4.02±5.18 # |
< 0.001 |
|
获卵数 |
11.00±6.25 |
6.56±3.81 * |
5.96±3.83 * |
< 0.001 |
|
减数分裂II期卵数 |
9.78±5.65 |
5.69±3.39 * |
5.49±3.70 * |
< 0.001 |
|
受精卵总数 |
7.12±4.67 |
4.55±3.08 * |
3.53±2.40 * |
< 0.001 |
|
获胚胎数 |
5.59±3.80 |
3.69±2.73 * |
3.00±2.22 * |
0.002 |
|
优胚数 |
2.90±2.20 |
2.11±1.85 * |
1.93±1.78 * |
0.034 |
与GnRH激动剂长方案组比较， * P < 0.05；与GnRH激动剂短方案组比较， # P < 0.05.