Table 2.
The effect of 2-AG on cardiac function in diabetic mice
| CON | DM | DM + 2-AG | P value | |
|---|---|---|---|---|
| HR, bpm | 515.57 ± 40.32 | 458.57 ± 32.44* | 521.14 ± 60.97# | 0.038 |
| LVEF, % | 80.97 ± 2.57 | 71.28 ± 6.72** | 78.83 ± 4.99# | 0.006 |
| LVFS, % | 43.66 ± 2.56 | 35.38 ± 5.34** | 41.09 ± 4.96# | 0.008 |
| LVIDd, mm | 3.50 ± 0.22 | 3.54 ± 0.30 | 3.48 ± 0.31 | 0.691 |
| LVIDs, mm | 1.97 ± 0.14 | 2.29 ± 0.24* | 2.00 ± 0.27# | 0.047 |
| LVFWd, mm | 0.84 ± 0.06 | 0.71 ± 0.04*** | 0.81 ± 0.07## | 0.002 |
| LVFWs, mm | 1.01 ± 0.07 | 0.90 ± 0.12* | 1.04 ± 0.10# | 0.029 |
| LVPWd, mm | 0.86 ± 0.05 | 0.77 ± 0.05* | 0.84 ± 0.08# | 0.040 |
| LVPWs, mm | 1.07 ± 0.08 | 0.97 ± 0.08* | 1.11 ± 0.11## | 0.020 |
| IVSd, mm | 0.89 ± 0.04 | 0.81 ± 0.04* | 0.89 ± 0.07# | 0.021 |
| IVSs, mm | 1.10 ± 0.08 | 1.03 ± 0.08 | 1.13 ± 0.10 | 0.102 |
Transthoracic echocardiography was performed on control and diabetic mice at the conclusion of the study. Cardiac parameters: HR, heart rate; LVEF, left ventricular ejection fraction %; LVFS, left ventricular fractional shortening %; LVIDd and LVIDs, left ventricular internal diameter end-diastole and end-systole; LVFWd and LVFWs, left ventricular forward wall at end-diastole and end-systole; LVPWd and LVPWs, left ventricular posterior wall at end-diastole and end-systole; IVSd and IVSs, interventricular septal thickness at end-diastole and end-systole. *P < 0.05, **P < 0.01, ***P < 0.001 compared with CON group; #P < 0.05, ##P < 0.01 with DM group. n = 7