Fig. 1. Pre-flight, in-flight (R-30, 30 days before returning to Earth), and post-flight (R+4, 4 days before returning to Earth) Multicolor Imaging in an astronaut that developed spaceflight associated neuro-ocular syndrome (SANS) during a spaceflight mission.

R-30 and R + 4 showcase choroidal folds (circled) as well as potential optic nerve head protrusion from SANS. Courtesy of NASA. Reprinted with permission from Ong et al. [38] under Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license (https://creativecommons.org/licenses/by-nc/4.0/).