Fig. 2. Blood–brain barrier disruption as a function of derated acoustic pressure, minimum pressure.

a Resultant disruption of the BBB at eight sonications across the cortex of marmoset SG shown via extravasation of Evans blue in Marmoset SG. b Extravasation of GBCA using in vivo MRI in Marmoset SG. c, d Same as (a, b) in Marmoset NE who was sonicated at lower acoustic pressures. e, f Same as (c, d) in Marmoset T.