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. 2023 Aug 2;14:4631. doi: 10.1038/s41467-023-40298-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B Parasite-derived t-SNE maps of individual cells showing Seurat cell clusters (A; n = 395 cells; cluster 0, n = 109 cells; cluster 1, n = 90 cells; cluster 2, n = 66 cells; cluster 3, n = 63 cells; cluster 4, n = 36 cells; cluster 5, n = 31 cells) and infected HepOrg cells (Pf liver stage; n = 40 cells) or erythrocytes (Pf blood stage; n = 355 cells), respectively B. Cluster 4 is enriched in infected cells from HepOrgs, while the remaining clusters mostly contain red blood cells. C Heatmap showing differentially expressed (DE) genes between liver and blood stage. D Violin plots showing DE genes enriched in the liver stage compared to the blood stage. Two-sided Mann–Whitney U (Wilcoxon rank-sum) test: *p < 0.05. CSP, p = 0.019; LISP1, p = 0.031; SLARP, p = 0.031. Box plots in D indicate the median (Q2), 25th percentile (Q1) and 75th percentile (Q3) with the whiskers showing the minimum (Q1 – 1.5 × interquartile range) and maximum (Q3 + 1.5 × interquartile range). See also Supplementary Data 4. Source data are provided as a Source data file and Supplementary Data 7.