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. 2023 Aug 2;9:283. doi: 10.1038/s41420-023-01582-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A MCT4 and PAK4 protein levels in the tumors were investigated using an immunohistochemistry assay. Scale bars = 100 μm. B Tumor volumes were recorded every 4 days from 7 days post-injection until the 19th day. C Tumor weights of mice in each group were recorded after dissection (n = 5 per group). D, E Typical IVIS photographs of three groups of subcutaneous tumors were obtained. Total fluorescence intensity ROI counts was proceeded to detect the cellular activity of subcutaneous tumors (n = 3 per group). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.