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. 2023 Aug 2;13:12556. doi: 10.1038/s41598-023-39152-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pediatric T-ALL bone marrow blast expression profiles. (a) Bar plot showing sample-wise percent composition of each cluster in the merged Dx T-ALL and control samples Seurat object as indicated by the legend. (b) Heatmap (downsampled randomly to 500 cells each cell type except DCs) showing scaled expression of canonical markers for different cell types across annotated clusters. Red and blue indicate upregulation and downregulation, respectively. (c) Heatmap showing scaled expression of select top cluster distinguishing genes in majority patient specific blast clusters with cluster numbers on the top. (d) Feature plot of the merged Dx T-ALL and control samples showing combined expression of genes SOX4, JUN, STMN1, CD99, TUBA1B. (e) Relative expression of the indicated markers in control BM samples (blue) vs pediatric T-ALL samples (red). The asterisk denotes significance (P < 0.0001). (f) Heatmap showing pathways commonly dysregulated in different T-ALL patient blast clusters using the IPA analysis tool (Qiagen). The color scale on the right represents the Z-score indicating the extent of upregulation (red) or downregulation (blue). (g) Upstream regulatory molecules significantly activated (red) or inhibited (blue), as denoted by the color scale (Z-score) to the right, in the different T-ALL patient blast clusters (x-axis).