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. 2023 Aug 2;13:12556. doi: 10.1038/s41598-023-39152-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparing T-ALL BM microenvironment at Dx and EOI. (a) Bar-plot showing relative percent of blasts, T cells, NK cells, B cells, Erythroid cells, Monocytes, Dendritic cells (DCs) and Progenitor cells (Prog.) at Dx (red) and EOI + Relapse (blue). (b, e) Heatmaps showing scaled expression of genes derived from differential gene expression analysis between matched Dx and EOI (b) B cells from cluster 7 or (e) monocytes from clusters 13 and 17. Although the Relapse sample was not included in the analyses, it is shown in the heat map for comparison. Red, green and blue bars on top denote Dx, EOI and Relapse cells, respectively. (c) and (d) Bar plots showing Z-scores of selected pathways and upstream regulators that are activated (red) or inhibited (blue) in B cells at EOI relative to Dx based on differential gene expression generated using the IPA tool. Z-scores of selected regulators that are upregulated (f) or downregulated (g) in EOI monocytes relative to matched Dx samples.