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. 1999 Feb;73(2):1479–1491. doi: 10.1128/jvi.73.2.1479-1491.1999

FIG. 6.

FIG. 6

FIG. 6

FIG. 6

FIG. 6

Histological changes in the ovaries of nude mice infected with rVV. Hematoxylin-and-eosin-stained histological sections of ovaries taken from nude mice 5 days after infection with 106 PFU of VV-HA-TK, VV-HA-Mig, or VV-HA–Crg-2 are shown. (A) The rapid replication of VV-HA-TK to high titers in ovaries caused massive destruction of the ovarian stromal cells. (B and C) Partial destruction was observed in ovaries of mice infected with VV-HA–Crg-2 (B), and minimal destruction was observed in ovaries of mice infected with VV-HA-Mig (C). (D) A histological section from an uninfected control mouse is also shown. Magnification, ×100.