Table 3.
The risk factors associated with AE-ILD related to early death (within 90 days) in the univariate analysis.
| Long survival (90 ≥ days) n = 19 |
Early death (< 90 days) n = 14 |
Odds ratio | p | |
|---|---|---|---|---|
| Age | 77.42 ± 9.10 | 73.85 ± 8.04 | 1.540 | 0.214 |
| Male (%) | 16 (84.21%) | 10 (71.43%) | 0.788 | 0.374 |
| Smoking history (%) | 14 (73.68%) | 10 (71.43%) | 0.021 | 0.885 |
| IPF (%) | 14 (73.68%) | 10 (71.43%) | 0.021 | 0.885 |
| UIP + probable UIP on HRCT (%) | 18 (94.74%) | 12 (85.71%) | 0.794 | 0.372 |
| FVC (%) | 68.10 ± 19.02 | 78.57 ± 20.23 | 1.098 | 0.294 |
| DLco (%) | 43.02 ± 18.85 | 30.89 ± 11.31 | 1.211 | 0.271 |
| P/F ratio | 194.15 ± 83.21 | 272.76 ± 104.89 | 4.618 | 0.031 |
| WBC | 11,420.20 ± 4118.90 | 10,958 ± 2460.40 | 0.033 | 0.855 |
| CRP | 7.83 ± 6.81 | 11.68 ± 7.78 | 1.791 | 0.180 |
| D-dimer | 9.69 ± 14.05 | 4.69 ± 5.28 | 0.935 | 0.333 |
| KL-6 | 1235.68 ± 598.00 | 1504.17 ± 1026.00 | 0.105 | 0.745 |
| SP-D | 537.76 ± 425.11 | 424.80 ± 279.52 | 0.331 | 0.564 |
| LDH | 356.73 ± 84.73 | 365.66 ± 117.44 | 0.004 | 0.983 |
| IVCY (%) | 9 (47.37%) | 9 (64.29%) | 0.930 | 0.334 |
| Immunosuppressant (%) | 6 (31.57%) | 8 (57.14%) | 2.157 | 0.142 |
| Additional nintedanib administration (%) | 9 (47.37%) | 2 (14.29%) | 3.970 | 0.046 |
AE-ILD acute exacerbation of interstitial lung disease, ILD interstitial lung disease, OR odds ratio, IPF idiopathic pulmonary fibrosis, UIP usual interstitial pneumonia, HRCT high resolution computed tomography, FVC forced vital capacity, DLco diffusing capacity for carbon monoxide, P/F ratio PaO2/FiO2 ratio, WBC white blood cell, CRP c-related peptide, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, IVCY intravenous cyclophosphamide.