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. 2023 Aug 2;6:805. doi: 10.1038/s42003-023-05166-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative cases from 39 NSCLC specimens were analyzed by IHC staining with Skp2 and MLKL. b The percentage of samples displaying low or high Skp2 expression compared to the expression levels of MLKL. N = 39. c The relative proportions of protein expressions were illustrated as a pie chart. d Scatterplot showed a negative correlation between Skp2 and MLKL. e Kaplan–Meier analysis showing correlation between Skp2 or MLKL expression levels and overall survival (OS) of patients (n = 813) with NSCLC. The gene expression data and survival information were downloaded from the Gene Expression Omnibus (GEO) database, including GSE29013, GSE37745, GSE31210, and GSE157011 datasets, based on GPL570 platform. The plots were draw by the R software. p < 0.05 by log-rank (Mantel–Cox) test was considered to be a statistically significant difference.