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. 2023 May 4;9(5):367–377. doi: 10.1002/cjp2.324

Figure 2.

Figure 2

Representative NTRK1, NTRK2, and NTRK3 FISH results: (A) NTRK1 FISH showing the typical pattern wild type: two fusion signals (original magnification ×100); (B) NTRK1 FISH showing the typical pattern of rearrangement: one fusion signal (yellow arrow) and split 3′ (orange arrow) and 5′ (green arrow) signals, with a separation distance of at least two signal diameters between the green (green arrow) and orange (orange arrow) signals (original magnification ×100); (C) NTRK1 FISH showing one fusion signal (yellow arrow) and split 3′ (orange arrow) and 5′ (green arrow) signals, with a separation distance of less than two signal diameters between the green (green arrow) and orange signals (orange arrow) (original magnification ×100); (D) NTRK1 FISH showing an atypical pattern: two fusion signals (yellow arrows) and an isolated 5′ signal (green arrow) (original magnification ×100); (E) NTRK1 FISH showing copy number gain with four fusion signals (original magnification ×100); (F) NTRK1 FISH showing gene amplification with seven fusion signals (original magnification ×100); (G) NTRK2 FISH showing the typical wild type pattern: two fusion signals (original magnification ×100); (H) NTRK2 FISH showing the typical pattern of rearrangement: one fusion signal (yellow arrow) and split 3′ (orange arrow) and 5′ (green arrow) signals, with a separation distance of at least two signal diameters between the green (green arrow) and orange signals (orange arrow) (original magnification ×100); (I) NTRK2 FISH showing gene copy number gain with three fusion signals(original magnification ×100); (J) NTRK3 FISH showing the typical wild type pattern: two fusion signals (original magnification ×100); (K) NTRK3 FISH showing the typical pattern of rearrangement: one fusion signal (yellow arrow) and split 3′ (orange arrow) and 5′ (green arrow) signals, with a separation distance of at least two signal diameters between the green (green arrow) and orange signals (orange arrow)(original magnification ×100); (L) NTRK3 FISH showing copy number gain with four fusion signals (original magnification ×100).