TABLE 1.

Summary table of EC₅₀ and IC₅₀ values of the ten selected steroids. All EC₅₀ and IC₅₀ were generated following dose-response experiments in the absence (DMSO) or presence of steroids ranging from 90 μM to 0.3 nM EC₅₀/IC₅₀ units are in µM. ND: No data available.

Common name	Chemical structure	Steroid class	EC50 (±SD)	IC50 (±SD)	Maximum serum level	Physiological presence	Common use	References
Progesterone		Progestagen	0.003 (±0.001)	0.006 (±0.002)	3 nM (male)	Yes	Birth control	Löfgren and Bäckström (1990)
					60 nM (female)
Stanozolol		Androgen	0.285 (±0.328)	0.194 (±0.045)	ND	No	Anabolic-Androgenic Steroids (AAS)	ND
Pregnenolone		Progestagen	0.073 (±0.016)	0.199 (±0.008)	12 nM	Yes	Endometriosis	Hill et al. (1999)
Dydrogesterone		Progestagen	0.130 (±0.103)	0.245 (±0.042)	52 nM	No	Luteal insufficiency infertility	Abdel-Hamid et al. (2006)
Estropipate		Estrogen	0.161 (±0.017)	0.288 (±0.010)	0.29 nM	No	Ovarian failure	Barnes and Levrant (2007)
Medrysone		Corticosteroid	0.240 (±0.103)	0.569 (±0.275)	ND	No	Anti-inflammatory	ND
Deoxycorticosterone		Mineralocorticoid	0.302 (±0.062)	0.523 (±0.081)	0.19 nM	Yes	Adrenocortical insufficiency	Oddie et al. (1972)
Epiandrosterone		Androgen	0.209 (±0.033)	0.628 (±0.102)	9 nM	Yes	AAS	Lewis et al. (1997)
Nandrolone		Androgen	0.306 (±0.033)	0.711 (±0.109)	19 nM	No	AAS; Anemia	Bagchus et al. (2005)
Testosterone		Androgen	0.407 (±0.062)	1,107 (±0.157)	11.6 nM	Yes	Sexual dysfunction (men); hot flashes (women)	Groepenhoff et al. (2021)
Dehydroisoandosterone 3-acetate (DHEA)		Androgen	0.593 (±0.043)	1,745 (±0.488)	53 nM	Yes	Depression, Supplement	Habib et al. (2021)