Table 2.

Summary of clinical cases of Cedecea lapagei

Author	Year	Country	Age	Sex	Medical diagnosis	Clinical presentation	Comorbidities	Diagnostic method	Antimicrobial susceptibility testing (antibiogram)	Antibiotic treatment	Outcome
Duperret et al.14	2020	United States	45	Male	Sinusitis	Foul rhinorrhea, sinus headache, and fever	Asthma	Culture from purulent nasal secretions	Resistant to: amoxicillin/clavulanate, ampicillin, and cefazolin Sensitive to: ciprofloxacin, gentamicin, meropenem, tetracycline, and tobramycin Intermediate sensitivity to: cefuroxime	Oral ciprofloxacin + nasal gentamicin/dexamethasone	Patient recovered (discharged)
Hai et al.7	2020	Vietnam	38	Male	Pneumonia and septic shock	Fatigue, cough, sputum, myalgia, fever, and shortness of breath	Diabetes mellitus type 2	Sputum culture	Resistant to: trimethoprim/ sulfamethoxazole Sensitive to: piperacillin/ tazobactam, ceftazidime, ceftriaxone, cefazolin, cefoxitin, aztreonam, imipenem, meropenem, amikacin, gentamicin, tobramycin, levofloxacin, and ciprofloxacin Intermediate sensitivity to: piperacillin	IV meropenem + IV ciprofloxacin	Patient recovered (discharged)
Ramaswamy et al.15	2019	India	35 days	Male	Nosocomial pneumonia and sepsis	Poor peripheral pulses, lethargy, fever, and severe respiratory distress	Late preterm	Blood culture	Resistant to: meropenem, colistin, amikacin, gentamycin, and ceftazidime Sensitive to: piperacillin, piperacillin/ tazobactam, trimethoprim/ sulfamethoxazole, ciprofloxacin, and levofloxacin	IV piperacillin/ tazobactam	Patient recovered (discharged)
Chavez Herrera et al.16	2018	Mexico	52	Male	Infection of hemorrhagic bullae causing necrotizing fasciitis and septic shock	Fever, pain, edema in his right lower limb, and multiple organ failure	Liver cirrhosis and treated hypertension	Bullae fluid culture	Resistant to: ampicillin, cefazolin, and imipenem Sensitive to: amikacin, aztreonam, ceftriaxone, ceftazidime, cefotaxime, ciprofloxacin, cefepime, cefuroxime, cefotetan, gentamicin, levofloxacin, meropenem, moxifloxacin, and piperacillin/ tazobactam Intermediate sensitivity to: ampicillin/sulbactam	IV clindamycin + IV ceftriaxone	Death
Kury et al.17	2017	Brazil	110 days	Male	Ventilator-associated pneumonia and sepsis	Fever and yellow sputum	Ischemic encephalopathy sequelae and chronic lung disease	Cultures from blood and tracheal aspirates	Resistant to: NR Sensitive to: piperacillin, imipenem, amikacin, gentamycin, ciprofloxacin, levofloxacin, meropenem, and trimethoprim/ sulfamethoxazole	IV meropenem	Patient recovered (discharged)
Biswal et al.18	2015	India	50	Male	Ulcer and pus formation at the cancer site	Fever and pain at the local site of ulcer, radiating to ear and forehead	Squamous cell carcinoma of the right buccal mucosa undergoing chemotherapy	Culture of pus samples from the ulcer site	Resistant to: ampicillin/sulbactam, tetracycline, and tigecycline Sensitive to: amikacin, gentamicin, ceftazidime, ceftriaxone, cefepime, ciprofloxacin, meropenem, and trimethoprim/ sulfamethoxazole	IV ciprofloxacin	Patient recovered (discharged)
Salazar et al.6	2013	Ecuador	24	Male	Traumatic wound infection	Fever, poor condition of healing tissue, increased discharge, and bad odor	No comorbidities	Culture of secretion obtained from granulation tissue	Resistant to: ampicillin and ampicillin/ sulbactam Sensitive to: cefuroxime, amikacin, trimethoprim/ sulfamethoxazole, ciprofloxacin, cefotaxime, carbapenems	IV ampicillin/sulbactam	Patient recovered (discharged)
Hong et al.19	2015	South Korea	76	Male	Pneumonia	Fever and dyspnea	Chronic obstructive pulmonary disease	Sputum culture	Resistant to: amoxicillin/clavulanate and cefoxitin Sensitive to: piperacillin, cefotaxime, ceftazidime, cefepime, imipenem, amikacin, ciprofloxacin, tetracycline, and trimethoprim/ sulfamethoxazole	IV cefpodoxime	Patient recovered (discharged)
Sanchez-Lopez et al.5	2013	Mexico	34	Male	Pneumonia	Fever, dyspnea, bilateral alveolar infiltrates, copious yellow sputum, and disseminated intravascular coagulation	Acute promyelocytic leukemia	Sputum culture	Resistant to: amikacin, ampicillin, aztreonam, cefazolin, cefepime, ceftriaxone, ciprofloxacin, ertapenem, imipenem, meropenem, moxifloxacin, nitrofurantoin, piperacillin/ tazobactam, and trimethoprim/ sulfamethoxazole Sensitive to: tigecycline Intermediate sensitivity to: ampicillin/sulbactam, gentamicin, and tobramycin	IV cefepime + IV vancomycin	Patient recovered (discharged)
Yetkin et al.20	2008	Turkey	38	Male	Pneumonia from the aspiration of upper airway secretion	Fever, dyspnea	Subarachnoid hemorrhage and chronic obstructive pulmonary disease	Culture from bronchoalveolar lavage fluid	Resistant to: amoxicillin, ampicillin, amoxicillin/clavulonate, and cephalothin Sensitive to: amikacin, ciprofloxacin, trimethoprim/ sulfamethoxazole, imipenem, aztreonam, cefepime, ceftriaxone, ceftazidime, cefotaxime, cefuroxime, piperacillin / tazobactam, gentamicin, piperacillin, and tetracycline	IV amikacin + IV vancomycin + IV meropenem	Death
Dalamaga et al.21	2008	Greece	47	Male	Wound infection	Fever, full-thickness burns in the right knee, and erythema, vesicles, and ulcerations in the left knee	Diabetes mellitus type 2	Blood and wound cultures	Resistant to: gentamicin, tobramycin, cephalothin, cefuroxime, cefoxitin, ceftazidime, tetracycline, and ampicillin Sensitive to: amikacin, meropenem, cefotaxime, cefepime, aztreonam, amoxicillin/clavulanate, piperacillin/tazobactam, trimethoprim/ sulfamethoxazole, ciprofloxacin, and levofloxacin	IV cefotaxime + IV amikacin	Patient recovered (discharged)
Davis and Wall4	2006	United States	55	Male	Peritonitis	Fever, abdominal pain, and cloudy dialysis effluent	Hypertension, orthotopic liver transplantation secondary to cirrhosis related to hepatitis C, continuous peritoneal dialysis, and end-stage renal disease secondary to glomerular disease	Culture from peritoneal fluid	NR	IV vancomycin + IV gentamicin	Patient recovered (discharged)
Mohamud et al.22	2022	Somalia	55	Male	Urinary tract infection	Acute exacerbations of renal failure and irritative voiding symptoms	Chronic renal failure, uncontrolled diabetes mellitus type 2, and hypertension	Culture from urine	Resistant to: ceftriaxone, cefazolin, ceftazidime, cefixime, ampicillin, and amoxicillin/clavulanate Sensitive to: amikacin, gentamicin, trimethoprim/ sulfamethoxazole, ciprofloxacin, levofloxacin, imipenem, and ertapenem	Oral levofloxacin	Patient recovered (discharged)
Cárdenas et al.23	2015	Colombia	47	Male	Acute osteomyelitis	Fever, edema, and erythema in the surgical area	No comorbidities	Culture from bone biopsy	Sensitive to: ertapenem	IV oxacillin + rifampicin empirically, switched to ertapenem after culture	Patient recovered (discharged)
Arellano Aguilar et al.28	2016	Mexico	67	Female	Bacteremia and burns on 20% of body surface	Burns in the granulation stage with moderate edema	Diabetes mellitus type 1, hypertension, and dyslipidemia	Culture from bronchial aspirate and blood culture	Resistant to: ampicillin, amikacin, and piperacillin/ tazobactam Sensitive to: meropenem and imipenem	IV piperacillin/ tazobactam + caspofungin initially, switched to linezolid on day 20 + imipenem/cilastatin on day 24	Patient recovered (discharged)
Çekin et al.24	2014	Turkey	40	Male	Urinary tract infection	Fever	Quadriplegia and use of urinary catheter	Culture from urine	Resistant to: ampicillin, gentamicin, tobramycin, cefazolin, cephalothin, amikacin, ampicillin/sulbactam, ertapenem, imipenem, meropenem, piperacillin, piperacillin/ tazobactam, cefepime, cefoxitin, cefotaxime, cefuroxime, and aztreonam Sensitive to: ciprofloxacin, levofloxacin, and trimethoprim/ sulfamethoxazole	IV ciprofloxacin	Patient recovered (discharged)
Islam et al.25	2016	India	First hours of life	Female	Sepsis with pneumonia	Respiratory distress immediately after birth	Meconium-stained amniotic fluid and low birth weight	Blood culture	Resistant to: amoxicillin/clavulonate, ceftazidime, ceftriaxone, trimethoprim/sulfamethoxazole, gentamycin, cefuroxime, and piperacillin/tazobactam Sensitive to: ciprofloxacin and imipenem	IV amikacin + IV ciprofloxacin	Patient recovered (discharged)
Ahmad et al.8	2017	India	26 days	Female	Late-onset sepsis	NR	Preterm, apnea	Blood culture	Resistant to: imipenem, meropenem, aztreonam, ceftazidime, cefotaxime, cefoxitin, cefepime, and cefoperazone/sulbactam	IV cefotaxime + IV amikacin	Patient recovered (discharged)
Deveci and Arpag26	2021	Turkey	76	Male	Pneumonia	Fever, shortness of breath, cough, sputum, wheezing, and impaired consciousness	COVID-19 2 weeks ago	Sputum culture	Resistant to: amoxicillin/clavulanate, piperacillin/ tazobactam, cefuroxime, cefuroxime acetil, ceftriaxone, ceftazidime, cefepime, amikacin, gentamicin, ciprofloxacin, tigecycline, and colistin Intermediate sensitivity to: meropenem and trimethoprim/ sulfamethoxazole	IV meropenem + IV moxifloxacin	Patient recovered (discharged)
González Rivera et al.27	2022	Mexico	57	Male	Pneumonia and septic shock	Fever, dyspnea, decreased amplection, use of accessory musculature with oxygen through nasal prongs at 5 L per minute, increased vocal vibrations on palpation, and bilateral infrascapular crepitant rales	HIV treatment discontinuation for the last 3 years	Culture from bronchial aspirate	Resistant to: ampicillin, gentamicin, tobramycin, cefazolin, cephalothin, amikacin, ampicillin/sulbactam, ertapenem, imipenem, meropenem, piperacillin, cefepime, cefotaxime, cefuroxime, aztreonam, ciprofloxacin, levofloxacin, and trimethoprim/ sulfamethoxazole	NR	Death

IV = intravenous; NR = not reported. Age is shown as years unless otherwise noted.