Table 5.
Comparison of infection type, NS1 antigen, serotype, and plasma viremia load in patients with severe dengue with and without acute kidney injury
| Characteristics | Tested cases | Non-AKI patients | AKI patients | P value |
|---|---|---|---|---|
| Infection type,* N (%) | 0.566 | |||
| Primary infection | 57 (66.3) | 42 (64.6) | 15 (71.4) | |
| Secondary infection | 29 (33.7) | 23 (35.4) | 6 (28.6) | |
| NS1 antigen,* N (%) | 0.646 | |||
| Positive | 105 (96.3) | 62 (95.4) | 43 (97.7) | |
| Negative | 4 (3.7) | 3 (4.6) | 1 (2.3) | |
| Serotype,* N (%) | 0.134 | |||
| DENV-1 | 98 (95.1) | 72 (97.3) | 26 (89.7) | |
| DENV-2 | 5 (4.9) | 2 (2.7) | 3 (10.3) | |
| Viral RNA, N (%) | 0.056 | |||
| Positive | 177 (97.3) | 116 (99.1) | 61 (93.8) | |
| Negative | 5 (2.7) | 1 (0.9) | 4 (6.2) | |
| Viral load (3–7 days)*† (log10 copies/mL), median (IQR) | 3.9 (2.4–6.4) | 4.0 (2.5–6.7) | 3.7 (2.0–6.0) | 0.573 |
AKI = acute kidney injury; DENV = dengue virus; IQR = interquartile range; NS1 = nonstructural protein 1.
*
Data are for patients with dengue recruited from Guangzhou Eighth People’s Hospital.
†
Indicates days after the onset of the disease.