Table 4.

The results of the drug release kinetics behavior

Release model name	Release model equation	Model parameters	Parameters for commercial ampule	Parameters for loaded NLC-based hydrogel
Zero-order	$Q_t=Q_0+\text{k}t$	Qt = amount of released drug at time t Q0 = initial amount of drug at buffer solution k = rate constant	k = 14.542 R2 = 0.837	k = 8.385 R2 = 0.726
First-order	$C_t=C_0\text{ exp }(-\text{k}t)$	Ct = drug concentration in NPs at time t C0 = initial drug concentration in NPs k = rate constant	k = 0.0007 R2 = 0.792	k = 0.0008 R2 = 0.809
Hixson–Crowell	$Q_0{}^{1/3}-Q_t{}^{1/3}=\text{k}t$	Qt = amount of released drug at time t Q0 = initial amount of drug at buffer solution k = rate constant	k = 0.0017 R2 = 0.758	k =0.002 R2 = 0.783
Higuchi	$Q_t=\text{k}{t}^{0.5}$	Qt = amount of released drug at time t k = rate constant	k = 1.681 R2 = 0.839	k = 3.0685 R2 = 0.875
Korsmeyer–Peppas	$C_t/C_0=\text{k}{t}^n$	Ct = amount of released drug at time t C0 = initial amount of drug at NPs k = rate constant n = diffusion exponent	N = 0.186 k = 26.490 R2 = 0.931	N = 0.478 k = 3.764 R2 = 0.987

NLC = nanostructured lipid carrier.