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. 2023 Aug 3;62(2):2201374. doi: 10.1183/13993003.01374-2022

FIGURE 2.

FIGURE 2

Cigarette smoke impairs PolyI:C and virus-induced upregulation of the immunoproteasome in vivo. a) Low molecular-weight protein (LMP)2 and LMP7 expression in mouse lungs 24 h after treatment with 10 μg PolyI:C following 24 days of cigarette smoke (CS) exposure. Densitometric analysis of LMP2 and LMP7 expression normalised to β-actin loading with mean of controls (Ctrl) without PolyI:C treatment set to 1 (median, interquartile range). b) LMP2 and LMP7 expression in mouse lungs after 28 days of cigarette exposure and subsequent infection with murine γ-herpesvirus (MHV)-68 for 7 days. Densitometric analysis of LMP2 and LMP7 expression normalised to β-actin with air mock control set to 1 (median, interquartile range). Kruskal–Wallis test with Dunn's post-test; *: p<0.05, **: p<0.01, ****: p<0.0001.