Table 2.
Knockout Mouse Models for Inflammatory Bowel Disease
| Conventional KO | Cell specific KO | Inducible KO |
|---|---|---|
| Ahr KO (ROR+/-) | C1galt1/C3Gnt KO | AGR2 iKO |
| ATF4 KO | CD4-PDK1 KO | C1galt1 iKO |
| A20 KO | CD4-TSC1 KO | Enteric glia iKO |
| Bach2 KO | CD4-Uhrf1 KO | Epi-FASyn iKO |
| Cbl-b KO | CD4-A, DAR1 KO | SHIP iKO |
| Cgamma KO | CD11-Cnb1 KO | STAT3 iKO |
| CRF2-4 KO | CX3CR1-IL10Rα KO | TAK1 iKO |
| Gαi2 KO | DC-TGFR II KO | |
| GPX1/2 double KO | DC-β8 KO | |
| IL1Rα KO | epi-AP1B KO | |
| IL2 KO | epi-Casp8 KO | |
| IL2Rα KO | epi-C1galt1 KO | |
| IL2Rβ KO | epi-IKK1/IKK2 dKO | |
| IL2 KO x β2-MG KO | epi-IRE1α KO | |
| IL10 KO | epi-NEMO KO | |
| Itch KO | epi-PTPN11 KO | |
| K8 KO | epi-RBPJ KO | |
| Lcn2/IL10 KO | epi-RelA KO | |
| Mdr1α KO | epi-TAK1 KO | |
| MHC class-II KO | epi-XBP1 KO | |
| Muc2 KO | hema-CD51 KO | |
| Nr2f6 KO | IEC-Cosmc KO | |
| Rhbdf2 KO | MΦ-STAT3 KO | |
| SHIP KO | Tcell-Blimp-1 KO | |
| TCRα KO | T cell-Pggt1b KO | |
| TCRβ KO | Treg-GARP KO | |
| TGFβ KO | Treg-IL10 KO | |
| TLR5 KO | Treg-Tbet/GATA3 dKO | |
| WASP KO | Thumus-Atg5 KO | |
Ahr, aryl hydrocarbon receptor; AGR2, anterior gradient protein 2 homolog; AP1B, adaptor protein 1B; ATF4, activating transcription factor; Bach2, broad complex-tramtrack-bric a brac and Cap’n’collar homology 2; Blimp, B-lymphocyte-induced maturation protein; Bach2, BTB domain and CNC homolog 2; C1galt1, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Casp8, caspase 8; CD4, CD4 positive T cells; Cbl-b, Casitas B cell lymphoma b; CRF, corticotropin-releasing factor; CX3CR1, CX3C motif chemokine receptor 1; DC, dendritic cells; epi, epithelial cells; GATA3, GATA binding protein 3; GARP, glycoprotein-A repetitions predominant protein; GPX1/2, glutathione peroxidases 1 and 2; IEC, intraepithelial lymphocytes; IKK, I kappa B kinase; iKO, inducible knockout; IL, Interleukin; IRE, inositol-requiring enzyme; Itch, itchy E3 ubiquitin protein ligase; KO, knockout; Lcn2, lipocalin-2; Mφ, macrophages; Mdr1α, multidrug resistance protein 1α; MHC, major histocompatibility complex; Muc2, mucin 2; NEMO, NF-kappa-B essential modulator; Nr2f6, nuclear receptor subfamily 2; group F, member 6; PDK1, 3-phosphoinositide-dependent protein kinase-1; Pggt1b, protein geranylgeranyl transferase type 1 subunit beta; PTPN11, tyrosine-protein phosphatase non-receptor type 11; Rhbdf2, rhomboid 5 homolog 2; ROR, RAR-related orphan receptor; SHIP, SH-2 containing inositol 5’ polyphosphatase; STAT, signal transducer and activator of transcription; TAK1, transforming growth factor-beta-activated kinase 1; TCR, T cell receptor; TGFβ, transforming growth factor beta; TLR, Toll-like receptor; Treg, regulatory T cell; TSC1, tuberous sclerosis complex 1; Uhrf1, ubiquitin-like, containing PHD and RING finger domains, 1; WASP, Wiskott-Aldrich syndrome protein.