Figure 1.

System setup. (a) CD44 (human) sequence used in this study with the TMD highlighted by dark underline. The basic residues close to S291 are marked in red. (b) Left panel: schematic diagram of CD44 (upper) and FERM (lower) structure. The TMD and CTD are displayed in dark green, and the two conserved amino acids S291 and S325 are highlighted with blue spheres. The FERM is represented by three subdomains: F1 (gold), F2 (yellow), and F3 (orange). Right panel: snapshot of the starting configuration of the simulated system. The proteins are shown with backbone only. POPC and PIP2 lipids are presented in gray and mauve, respectively. Waters and ions are omitted for clarity. To see this figure in color, go online.