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. 2023 May 22;122(13):2675–2685. doi: 10.1016/j.bpj.2023.05.021

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© 2023 Biophysical Society.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Behavior of CD44-CTD before FERM binding. (a) Representative conformations of CD44-WT, CD44-S291p, and CD44-S325p in the 95% POPC/5% PIP2 membrane. (b) Density maps of the distribution of PIP2 relative to the TMD. Results were obtained from averaging the last 2.5 μs of all 10 replicas. The CD44 is prefixed in the box center for analysis. (c) Protein-lipid contact distribution of the CTD with the lipid phosphates under different phosphorylation states. Contact intensity of (d) the 291^st residue and (e) the 325^th residue with lipid phosphates of POPC (left) and PIP2 (right) in the three phosphorylation states. To see this figure in color, go online.