TABLE 3.
Adherence and Persistence Among Switchers (Used More than 1 Anticoagulant During the Follow-Up Period) of Atrial Fibrillation Patients
| Follow-up Period | Prevalent Cohort | Incident Cohort | |||||
|---|---|---|---|---|---|---|---|
| 6 Months | 9 Months | 12 Months | 6 Months | 9 Months | 12 Months | ||
| Number of patients, n | 180 | 125 | 81 | 44 | 25 | 6 | |
| Switching patterns | |||||||
| Average time to first switch, mean (SE) | 61.1 (48.8) | 92.2 (82.5) | 126.4 (114.6) | 74.09 (51.4) | 87.58 (66.3) | 102.0 (84.0) | |
| Drug switched, n (%) | Warfarin | 175 (97.2) | 119 (95.2) | 73 (90.1) | 43 (97.7) | 25 (100) | 6 (100) |
| Rivaroxaban | 5 (2.8) | 6 (4.8) | 8 (9.9) | 1 (2.3) | — | — | |
| Adherence to anticoagulants | |||||||
| MPR analysis | Mean MPR, mean (SE) | 0.84 (0.21) | 0.78 (0.24) | 0.75 (0.27) | 0.82 (0.23) | 0.79 (0.24) | 0.81 (0.30) |
| Adherent (MPR ≥ 0.80), n (%) | 123 (68.3) | 65 (52.0) | 42 (51.9) | 31 (70.5) | 15 (60.0) | 4 (66.7) | |
| Nonadherent (MPR < 0.80), n (%) | 57 (31.7) | 60 (48.0) | 39 (48.1) | 13 (29.5) | 10 (40.0) | 2 (33.3) | |
| Persistence to anticoagulants | |||||||
| Main analysis | |||||||
| Gap = 60 days | Nonpersistent, n (%) | 38 (21.1) | 55 (44.0) | 38 (46.9) | 8 (18.2) | 12 (48.0) | 3 (50.0) |
| Sensitivity analyses | |||||||
| Gap = 15 days | Nonpersistent, n (%) | 112 (62.2) | 111 (88.8) | 62 (76.5) | 27 (61.4) | 22 (88.0) | 5 (83.3) |
| Gap = 30 days | Nonpersistent, n (%) | 77 (42.8) | 89 (71.2) | 50 (61.7) | 18 (40.9) | 17 (68.0) | 4 (66.7) |
| Gap = 90 days | Nonpersistent, n (%) | 17 (9.4) | 16 (12.8) | 29 (35.8) | 5 (11.4) | 9 (36.0) | 3 (50.0) |
Source: IMS Health LifeLink Health Plan Claims Database, 2010-2012.23
MPR = medication possession ratio; SE = standard error.