TABLE 4.
Adherence and Persistence to Dabigatran Among Nonswitchers (Used Only Dabigatran During the Follow-Up Period) of Atrial Fibrillation Patients
| Follow-up Period | Prevalent Cohort | Incident Cohort | |||||
|---|---|---|---|---|---|---|---|
| 6 Months | 9 Months | 12 Months | 6 Months | 9 Months | 12 Months | ||
| Number of patients | 2,713 | 1,588 | 687 | 364 | 213 | 90 | |
| Adherence to dabigatran | |||||||
| MPR analysis | Mean MPR, mean (SE) | 0.73 (0.30) | 0.69 (0.33) | 0.65 (0.35) | 0.72 (0.31) | 0.67 (0.33) | 0.59 (0.35) |
| Adherent (MPR ≥ 0.80), n (%) | 1,593 (58.7) | 847 (53.3) | 349 (50.8) | 216 (59.3) | 109 (51.2) | 37 (41.1) | |
| Nonadherent (MPR < 0.80), n (%) | 1,120 (41.3) | 741 (46.7) | 338 (49.2) | 148 (40.7) | 104 (48.8) | 53 (58.9) | |
| Persistence to dabigatran | |||||||
| Main analysis | |||||||
| Gap = 60 days | Nonpersistent, n (%) | 854 (31.5) | 763 (48.0) | 333 (48.5) | 130 (35.7) | 95 (44.6) | 52 (57.8) |
| Sensitivity analyses | |||||||
| Gap = 15 days | Nonpersistent, n (%) | 1,551 (57.2) | 1,317 (82.9) | 495 (72.1) | 212 (58.2) | 144 (67.6) | 71 (78.9) |
| Gap = 30 days | Nonpersistent, n (%) | 1,203 (44.3) | 1,024 (64.5) | 417 (60.7) | 162 (44.5) | 115 (54.0) | 58 (64.4) |
| Gap = 90 days | Nonpersistent, n (%) | 600 (22.1) | 344 (21.7) | 283 (41.2) | 94 (25.8) | 82 (38.5) | 46 (51.1) |
Source: IMS Health LifeLink Health Plan Claims Database, 2010-2012.23
MPR = medication possession ratio; SE = standard error.