TABLE 1.
Treatment Status During Post-Index Period
| Total Patients (N = 27,905) | MPR (Categorical) | Discontinued (n = 17,243) | |||
|---|---|---|---|---|---|
| MPR < 70% (n = 16,537) | MPR ≥ 70% (n = 11,368) | P Valuea | |||
| Index medication, n (%) b | |||||
| Alendronate | 15,917 (57.0) | 9,192 (55.6) | 6,725 (59.2) | < 0.001 | 9,585 (55.6) |
| Risedronate | 6,739 (24.1) | 4,070 (24.6) | 2,669 (23.5) | 4,217 (24.5) | |
| Ibandronate | 5,249 (18.8) | 3,275 (19.8) | 1,974 (17.4) | 3,441 (20.0) | |
| MPR within 12-month post-index period, median (SD)c | 53.5 (35.3) | 27.4 (19.4) | 91.4 (9.1) | < 0.001 | 30.0 (22.4) |
| Number of index drug prescriptions within 12-month post-index period, mean (SD) | 5.6 (4.3) | 4.1 (3.7) | 9.2 (3.2) | < 0.001 | 3.1 (2.5) |
| Index medication treatment patterns during 12-month post-index period | |||||
| Discontinued, n (%)d | 17,243 (61.8) | 15,984 (96.7) | 1,259 (11.1) | < 0.001 | 17,243 (100.0) |
| Mean time (days) to discontinuation mean (SD) | 95 (77.0) | 87 (70.0) | 199 (90.0) | < 0.001 | 82 (69.0) |
| Switched, n (%) | 1,168 (6.8) | 1,107 (6.7) | 61 (0.5) | 0.005 | 1,168 (6.8) |
| Mean time (days) to switch, mean (SD) | 72 (76.0) | 64 (66.0) | 216 (109.0) | < 0.001 | 53 (60.0) |
| Restart, n,(%) | 4,240 (15.2) | 3,495 (21.1) | 745 (6.6) | < 0.001 | 4,240 (24.6) |
| Mean time (days) to restart, mean (SD) | 220 (79.0) | 218 (78.0) | 226 (82.0) | 0.019 | 223 (77.0) |
| Total fractures within 13- to 24-months post-index period, n (%) | 822 (2.9) | 547 (3.3) | 275 (2.4) | < 0.001 | 573 (3.3) |
| Dorsal and lumbar | 339 (1.2) | 235 (1.4) | 104 (0.9) | 0.001 | 243 (1.4) |
| Hip, pelvis, femur, lower forearm, radius/ulna, humerus fracture | 372 (1.3) | 246 (1.5) | 126 (1.1) | 0.007 | 257 (1.5) |
| Other fracture | 165 (0.6) | 105 (0.6) | 60 (0.5) | 0.267 | 111 (0.6) |
| Total fractures within 25- to 36-month post-index period, n (%) | 1,035 (5.5) | 659 (6.0) | 376 (4.8) | < 0.001 | 686 (6.0) |
| Dorsal and lumbar | 425 (2.3) | 279 (2.5) | 146 (1.9) | 0.002 | 287 (2.5) |
| Hip, pelvis, femur, lower forearm, radius/ulna, humerus fracture | 484 (2.6) | 307 (2.8) | 177 (2.3) | 0.028 | 320 (2.8) |
| Other fracture | 215 (1.1) | 125 (1.1) | 90 (1.2) | 0.945 | 130 (1.1) |
a P values ≤ 0.05 are italicized.
b Index medication is the first medication of study interest on index date.
c MPR = (sum of days supply regardless of overlapping/365 days) × 100.
d Discontinuation = a gap of at least 60 days between 2 sequential prescription fills.
MPR = medication possession ratio; SD = standard deviation.