TABLE 2.
Demographics and Clinical Characteristics
| Total Patients (N = 27,905) | MPR (Categorical) | Discontinued (n = 17,243) | |||
|---|---|---|---|---|---|
| MPR < 70% (n = 16,537) | MPR ≥ 70% (n = 11,368) | P Valuea | |||
| Age, n (%) | |||||
| < 65 | 15,679 (56.2) | 9,324 (56.4) | 6,355 (55.9) | 0.427 | 9,651 (60.7) |
| ≥ 65 | 12,226 (43.8) | 7,213 (43.6) | 5,013 (44.1) | 7,592 (47.8) | |
| Mean age (SD) | 66.1 (9.7) | 66.1 (9.8) | 66.0 (9.7) | 0.705 | 66.2 (9.8) |
| Geographic region, n (%) | |||||
| Northeast | 5,983 (21.4) | 3,495 (21.1) | 2,488 (21.9) | < 0.001 | 3,674 (23.1) |
| Midwest | 9,872 (35.4) | 5,748 (34.8) | 4,124 (36.3) | 6,012 (37.8) | |
| South | 7,341 (26.3) | 4,521 (27.3) | 2,820 (24.8) | 4,658 (29.3) | |
| West | 4,709 (16.9) | 2,773 (16.8) | 1,936 (17.0) | 2,899 (18.2) | |
| Health plan type, n (%) | |||||
| HMO | 6,369 (22.8) | 3,809 (23.0) | 2,560 (22.5) | < 0.001 | 3,983 (25.1) |
| PPO | 16,425 (58.9) | 9,671 (58.5) | 6,754 (59.4) | 10,074 (63.4) | |
| Other | 5,111 (18.3) | 3,057 (18.5) | 2,054 (18.1) | 3,186 (20.0) | |
| Pre-index comorbidities during 12-month pre-index period, n (%) | |||||
| Deyo-Charlson Comorbidity Score, mean (SD) | 0.60 (1.07) | 0.64 (1.11) | 0.54 (1.01) | < 0.001 | 0.64 (1.11) |
| Anorexia nervosa | 9 (0.0) | 6 (0.0) | 3 (0.0) | 0.746 | 6 (0.0) |
| Celiac disease | 45 (0.2) | 25 (0.2) | 20 (0.2) | 0.650 | 25 (0.1) |
| Inflammatory bowel disease | 243 (0.9) | 162 (1.0) | 81 (0.7) | 0.018 | 156 (0.9) |
| Lactose intolerance | 99 (0.4) | 66 (0.4) | 33 (0.3) | 0.151 | 68 (0.4) |
| Lupus | 213 (0.8) | 140 (0.8) | 73 (0.6) | 0.059 | 142 (0.8) |
| Rheumatoid arthritis | 1,031 (3.7) | 676 (4.1) | 355 (3.1) | < 0.001 | 696 (4.0) |
| Asthma | 1,939 (6.9) | 1,241 (7.5) | 698 (6.1) | < 0.001 | 1,290 (7.5) |
| Stroke | 1,976 (7.1) | 1,234 (7.5) | 742 (6.5) | 0.003 | 1,307 (7.6) |
| Dementia | 336 (1.2) | 188 (1.1) | 148 (1.3) | 0.219 | 198 (1.1) |
| COPD | 1,672 (6.0) | 1,077 (6.5) | 595 (5.2) | < 0.001 | 1,120 (6.5) |
| Renal disease | 862 (3.1) | 543 (3.3) | 319 (2.8) | 0.024 | 561 (3.3) |
| Hyperparathyroidism | 229 (0.8) | 127 (0.8) | 102 (0.9) | 0.251 | 130 (0.8) |
a P values ≤ 0.05 are italicized.
COPD = chronic obstructive pulmonary disease; HMO = health maintenance organization; MPR = medication possession ratio; PPO = preferred provider organization; SD = standard deviation.