TABLE 1.
Input Parameters
| Parameters | Base-Case Values | References |
|---|---|---|
| Test inputs | ||
| Response rate—SOC | 46% (SD 36%) | Bradley (2018)26 |
| Relative benefit ratio for response—IDGx | 1.39 (SD 2.02) | N/A |
| Clinical inputs | ||
| Age of patient at baseline | 48 | Bradley (2018)26 |
| Mortality rates | ||
| Suicide rate (responders) | 0.09% | Olin (2012)11 |
| Suicide rate (nonresponders) | 0.16% | Olin (2012)11 |
| Relative risk of all-cause mortality (responders) | 1.0 | Arias (2017)35 |
| Relative risk of all-cause mortality (nonresponders) | 1.0 | Arias (2017)35 |
| Cost inputs, $ | ||
| Test | 2,000 | AltheaDx |
| Direct medical costs, annual (responders) | 8,675 | Mrazek (2014)12 |
| Direct medical costs, annual (nonresponders) | 14,837 | Mrazek (2014)12 |
| Indirect medical costs, annual (responders) | 3,234 | Mrazek (2014)12 |
| Indirect medical costs, annual (nonresponders) | 7,785 | Mrazek (2014)12 |
| Utility inputs | ||
| Responders | 0.81 | Sobocki (2006)53 |
| Nonresponders | 0.57 | Sobocki (2006)53 |
| Policy inputs | ||
| Time horizon (years) | 3 | N/A |
| Discount rate | 3% | Neumann (2016)27 |
| Catch-up year | 3 | Geddes (2003)30 |
IDGx = IDgenetix; N/A = not applicable; SD = standard deviation; SOC = standard of care.