. 2018 Oct;24(10):10.18553/jmcp.2018.24.10.1002. doi: 10.18553/jmcp.2018.24.10.1002

Table 3.

ERT/SRT-Related Inputs and Sources

Parameter (Dose)^a	Pack Size^a	Cost per Pack^a,b
Drug acquisition costs–ERT
Imiglucerase (47.4 U/kg)^c	1 × 400 U vial	1,586.00
Velaglucerase (47.4 U/kg)^c	1 × 400 U vial	1,377.00
Taliglucerase (47.4 U/kg)^c	1 × 200 U vial	779.45
Drug acquisition costs–SRT
Eliglustat (200 mg daily)^c,d	56 × 100 mg cap	23,800
Miglustat (300 mg daily)^c,d	90 × 100 mg cap	26,820
Parameter	Input Value	Source
Administration–ERT
Frequency of infusion^e	24 infusions/year
Administration cost by site of care–ERT
Home	$180^b	DataMart Multiplan (IMPACT) database^f
Outpatient, infusion center	$249^b
Outpatient, hospital	$369^b

^aFrom RED BOOK Online, 2017.22

^bAll costs are expressed in 2017 U.S. dollars.

^cFrom drug prescribing information.28-32

^dMedication possession ratio (MPR) = 92.3% (assumption).

^eFrom data on file, Sanofi Genzyme, December 31, 2015.

^fFrom unpublished claims analysis, DataMart Multiplan (IMPACT) database licensed from OPTUM Insight Life Science by Sanofi US Services, 2013. cap = capsules; ERT = enzyme replacement therapy; SRT = substrate reduction therapy; U = unit.