TABLE 1.
Demographic and Clinical Characteristics of Sample
| Characteristic | All Patients (N = 454) | Pomalidomide Patients (n = 264) | Carfilzomib Patients (n = 190) | P Value |
|---|---|---|---|---|
| Age, years, mean [SD] | 61.6 [9.3] | 61.7 [9.2] | 61.4 [9.6] | 0.671 |
| Gender, n (%) | ||||
| Female | 181 (39.9) | 110 (41.7) | 71 (37.4) | 0.356 |
| Male | 273 (60.1) | 154 (58.3) | 119 (62.6) | |
| Geographic region, n (%) | ||||
| Northeast | 113 (24.9) | 81 (30.7) | 32 (16.8) | 0.007 |
| Midwest | 149 (32.8) | 76 (28.8) | 73 (38.4) | |
| South | 160 (35.2) | 89 (3.7) | 71 (37.4) | |
| West | 32 (7.0) | 18 (6.8) | 14 (7.4) | |
| Payer type, n (%) | ||||
| Commercial | 317 (69.8) | 188 (71.2) | 129 (67.9) | 0.210 |
| Medicare risk | 10 (2.2) | 7 (2.7) | 3 (1.6) | |
| Self-insured group | 119 (26.2) | 67 (25.4) | 52 (27.4) | |
| Other/unknown | 8 (1.8) | 2 (0.8) | 6 (3.2) | |
| Charlson Comorbidity Index score, mean [SD] | 4.2 [2.3] | 4.0 [2.2] | 4.4 [2.4] | 0.069 |
| Baseline comorbid conditions of interest, n (%) | ||||
| Acute or chronic kidney disease | 117 (25.8) | 55 (20.8) | 62 (32.6) | 0.005 |
| Anemia | 263 (57.9) | 143 (54.2) | 120 (63.2) | 0.056 |
| Arterial thrombosis | 10 (2.2) | 6 (2.3) | 4 (2.1) | 0.905 |
| Cardiac arrhythmia | 89 (19.6) | 52 (19.7) | 37 (19.5) | 0.953 |
| Cardiac valvular disease | 43 (9.5) | 24 (9.1) | 19 (10.0) | 0.744 |
| Cerebrovascular disease | 10 (2.2) | 4 (1.5) | 6 (3.2) | 0.239 |
| Chronic pain/fibromyalgia | 94 (20.7) | 50 (18.9) | 44 (23.2) | 0.274 |
| Diabetes | 89 (19.6) | 49 (18.6) | 40 (21.1) | 0.509 |
| Dyslipidemia | 123 (27.1) | 72 (27.3) | 51 (26.8) | 0.919 |
| Hypertension | 214 (47.1) | 117 (44.3) | 97 (51.1) | 0.156 |
| MI/CAD | 46 (10.1) | 30 (11.4) | 16 (8.4) | 0.305 |
| Neutropenia | 79 (17.4) | 38 (14.4) | 41 (21.6) | 0.046 |
| Osteoarthritis | 213 (46.9) | 120 (45.5) | 93 (48.9) | 0.462 |
| Renal failure/dialysis | 44 (9.7) | 17 (6.4) | 27 (14.2) | 0.006 |
| Smoking or history of smoking | 42 (9.3) | 19 (7.2) | 23 (12.1) | 0.075 |
| Venous thrombosis | 42 (9.3) | 26 (9.8) | 16 (8.4) | 0.605 |
| Pre-index ASCT, n (%) | 141 (31.1) | 91 (34.5) | 50 (26.3) | 0.064 |
| Available months of follow-up, mean [SD] | 8.9 [5.4] | 9.3 [5.9] | 8.2 [4.5] | 0.032 |
ASCT = autologous stem cell transplant; CAD = coronary artery disease; MI = myocardial infarction; SD = standard deviation.