TABLE 2.
Patient Demographics and Clinical Characteristics
| Characteristic | Total (N = 1,175) | Second Line (n = 659) | Third Line (n = 326) | > Fourth Line (n = 190) | ||||
|---|---|---|---|---|---|---|---|---|
| Age, years | ||||||||
| Mean (SD) | 63.6 (± 10.1) | 63.6 (± 10.0) | 62.9 (± 10.0) | 64.5 (± 10.3) | ||||
| Median (range) | 64 (23-85) | 64 (29-85) | 63 (23-85) | 65 (28-85) | ||||
| Age group, years, n(%) | ||||||||
| < 45 | 35 | (3) | 18 | (3) | 11 | (3) | 6 | (3) |
| 45-54 | 170 | (14) | 98 | (15) | 50 | (15) | 22 | (12) |
| 55-64 | 424 | (36) | 240 | (36) | 116 | (36) | 68 | (36) |
| 65-74 | 371 | (32) | 205 | (31) | 110 | (34) | 56 | (29) |
| > 75 | 175 | (15) | 98 | (15) | 39 | (12) | 38 | (20) |
| Gender, n (%) | ||||||||
| Male | 865 | (74) | 487 | (74) | 244 | (75) | 134 | (71) |
| Female | 310 | (26) | 172 | (26) | 82 | (25) | 56 | (29) |
| Charlson Comorbidity Indexa | ||||||||
| Mean (SD) | 2.7 (± 1.1) | 2.7 (± 1.0) | 2.7 (± 1.1) | 2.7 (± 1.1) | ||||
| Median (range) | 2 | (2-9) | 2 | (2-7) | 2 | (2-9) | 2 | (2-6) |
| Score, n (%) | ||||||||
| 2 | 749 | (64) | 424 | (64) | 203 | (62) | 122 | (64) |
| 3 | 194 | (17) | 105 | (16) | 55 | (17) | 34 | (18) |
| 4 | 129 | (11) | 76 | (12) | 38 | (12) | 15 | (8) |
| 5-8 | 103 | (9) | 54 | (8) | 30 | (9) | 19 | (10) |
| Comorbid groups,b n (%) | ||||||||
| No comorbidity | 418 | (36) | 252 | (38) | 99 | (30) | 67 | (35) |
| Hypertension | 199 | (17) | 115 | (17) | 58 | (18) | 26 | (14) |
| Diabetes ± acute complications | 171 | (15) | 103 | (16) | 49 | (15) | 19 | (10) |
| Renal disease | 162 | (14) | 88 | (13) | 46 | (14) | 28 | (15) |
| Moderate/severe chronic kidney disease | 108 | (9) | 62 | (9) | 32 | (10) | 14 | (7) |
| Chronic pulmonary disease | 81 | (7) | 42 | (6) | 24 | (7) | 15 | (8) |
| Cardiovascular disease | 65 | (6) | 37 | (6) | 21 | (6) | 7 | (4) |
| Congestive heart failure | 60 | (5) | 32 | (5) | 17 | (5) | 11 | (6) |
| Rx-Risk-V Index | ||||||||
| Score, n (%) | ||||||||
| 0 | 361 | (31) | 211 | (32) | 98 | (30) | 52 | (27) |
| 1 | 109 | (9) | 66 | (10) | 23 | (7) | 20 | (11) |
| 2-3 | 239 | (20) | 133 | (20) | 71 | (22) | 35 | (18) |
| 4-5 | 221 | (19) | 133 | (20) | 57 | (17) | 31 | (16) |
| 6-9 | 228 | (19) | 107 | (16) | 73 | (22) | 48 | (25) |
| 10+ | 17 | (1) | 9 | (1) | 4 | (1) | 4 | (2) |
| Rx-Risk-V categories, n (%) | ||||||||
| No Rx-Risk-V categories | 361 | (31) | 211 | (32) | 98 | (30) | 52 | (27) |
| Pain | 474 | (40) | 263 | (40) | 138 | (42) | 73 | (38) |
| Ischemic heart disease/hypertension | 348 | (30) | 182 | (28) | 102 | (31) | 64 | (34) |
| Congestive heart failure/hypertension | 285 | (24) | 153 | (23) | 84 | (26) | 48 | (25) |
| Gastric acid disorder | 275 | (23) | 154 | (23) | 81 | (25) | 40 | (21) |
| Hyperlipidemia | 250 | (21) | 125 | (19) | 78 | (24) | 47 | (25) |
| Hypothyroidism | 247 | (21) | 129 | (20) | 67 | (21) | 51 | (27) |
| Hypertension | 198 | (17) | 102 | (15) | 53 | (16) | 43 | (23) |
| Anxiety and tension | 189 | (16) | 92 | (14) | 63 | (19) | 34 | (18) |
| Depression | 187 | (16) | 99 | (15) | 56 | (17) | 32 | (17) |
| All others | 573 | (49) | 304 | (46) | 170 | (52) | 99 | (52) |
| Prescriber geographic region, n (%) | ||||||||
| South | 420 | (36) | 234 | (36) | 114 | (35) | 72 | (38) |
| Midwest | 285 | (24) | 162 | (25) | 83 | (25) | 40 | (21) |
| Northeast | 245 | (21) | 153 | (23) | 64 | (20) | 28 | (15) |
| West | 224 | (19) | 109 | (17) | 65 | (20) | 50 | (26) |
| Unknown | 1 | (< 1) | 1 | (<1) | 0 | 0 | ||
| Prescriber affiliation, n (%) | ||||||||
| Academic center | 743 | (63) | 419 | (64) | 211 | (65) | 113 | (59) |
| Community practice | 227 | (19) | 124 | (19) | 62 | (19) | 41 | (22) |
| Unknown | 205 | (17) | 116 | (18) | 53 | (16) | 36 | (19) |
| Payer type,c n (%) | ||||||||
| Commerciald | 847 | (72) | 474 | (72) | 236 | (72) | 137 | (72) |
| Medicare | 252 | (21) | 138 | (21) | 72 | (22) | 42 | (22) |
| Medicaid | 24 | (2) | 17 | (3) | 5 | (2) | 2 | (1) |
| Other | 52 | (4) | 30 | (5) | 13 | (4) | 9 | (5) |
aMetastatic diagnosis excluded from Charlson Comorbidity Index.
bIncludes conditions occurring in > 5% of patients.
cBased on index prescription.
dIncludes Medicare Advantage.
SD = standard deviation.